Theory of Macromolecular conformations, 5p; 5A 1353
Will be given 1999/2000.
First lecture Monday 17 January 2000, 08:15-10:00, room F12 (Sing-Sing).
2nd lecture Friday 21 January 10-12 Q31
Wednesday 8-10 Q31
Thursday 10-12 Q32
Wednesday 16 February 8-10 Q25
Thursday 17 February 10-12 Q32
Wednesday 23 February 8-10 L41
Thursday 24 February 10-12 Q11 (Last lecture)
Teacher: Clas Blomberg, phone: 08-790 7176; email:firstname.lastname@example.org
To use statistical mechanical methods for describing the geometry of large
macromolecules (polymers), and from that provide a background of physical
properties, both for technically interesting artificial polymers, such
as polyethylene and polypropene, and for biological polymers: proteins
and nucleic acids, which are characterized by compact structures. Single
molecules as well as polymer materials are treated. The starting point
is the atomic structure and interaction energies between different atomic
groups. From this, various possible structures (conformations) are characterized.
Some background in statistical mechanics.
Monomers and macromolecules. Conformations. Random structures and
various mathematical models for these. The problem of excluded volume.
The theory of Flory-Huggins. Interactions between close atom groups and
their influence on the molecule structures. Characterization of some polymers
from this aspect.
Proteins. Conformations of amino acids; interactions between close groups.
Ramachandran- diagrams. Some structure types: -helices, -sheets. The relevance
of protein structure and structure changes. Methods for predicting structures.
Nucleic acids, DNA, RNA. Characterization of the conformations of nucleotides.
Various helical structures. Supercoiling. Couplings between base pairs.
Polymer materials, various states and transitions. Scaling properties
and dynamics based upon scaling ideas.
Solutions of given home exercises, which are to be discussed with
the examinator .
P. G. Des Gennes, Scaling Concepts in Polymer Physics. Cornell
Univ. Press, 1979.
G.E. Schultz, R.H.Schirmer, Principles of Protein Structure,